linoleate (18:2n6) to n-palmitoylglycine

Numerator Metabolite

Structure of linoleate (18:2n6)
Metabolite Accession: GCST90200354
Name: linoleate (18:2n6)
Hmdb Id: HMDB0006270,HMDB0000673
Super Pathway: NA
Sub Pathway: NA
Inchikey: OYHQOLUKZRVURQ

Denominator Metabolite

Structure of n-palmitoylglycine
Metabolite Accession: GCST90199923
Name: n-palmitoylglycine
Hmdb Id: HMDB0013034
Super Pathway: NA
Sub Pathway: NA
Inchikey: KVTFEOAKFFQCCX

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.357
Position:
46870761
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-21.348
Reference Allele:
C
-log10(P):
-231.152
MAF:
0.208
Beta (Num):
-0.021
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
0.336
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs1047891

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.245
Position:
211540507
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-16.540
Reference Allele:
C
-log10(P):
-139.824
MAF:
0.310
Beta (Num):
0.002
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.247
SE (Den):
0.016
No CNV overlap
rQTL cluster:
140
Reaction Distance:
NA
Closest Genes:
CPS1 LANCL1 MYL1 ACADL KANSL1L

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, Eicosanoid synthesis5[1], 6[2]

Denominator Metabolite Explanation:

N-acyl amino acid metabolism7[1], 8[2]

Ratio Explanation:

A higher ratio suggests decreased FAAH activity, leading to accumulation of its substrate N-palmitoylglycine relative to the unrelated fatty acid, linoleate.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced FAAH activity, indicated by the elevated ratio, is linked to protection against kidney injury.9[1], 10[2] This suggests that altered levels of FAAH substrates like N-palmitoylglycine influence renal pathophysiology, potentially mediating the observed association with chronic kidney disease and renal failure.9[3], 11[4]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data