n-palmitoylglycine to palmitoleate (16:1n7)

Numerator Metabolite

Structure of n-palmitoylglycine
Metabolite Accession: GCST90199923
Name: n-palmitoylglycine
Hmdb Id: HMDB0013034
Super Pathway: NA
Sub Pathway: NA
Inchikey: KVTFEOAKFFQCCX

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.351
Position:
46870761
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
21.507
Reference Allele:
C
-log10(P):
-234.569
MAF:
0.208
Beta (Num):
0.336
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.016
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.176
Position:
102075479
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
9.997
Reference Allele:
G
-log10(P):
-52.508
MAF:
0.176
Beta (Num):
0.048
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.128
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs1047891

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.248
Position:
211540507
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
17.112
Reference Allele:
C
-log10(P):
-149.481
MAF:
0.310
Beta (Num):
0.247
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-8.63e-04
SE (Den):
0.016
No CNV overlap
rQTL cluster:
140
Reaction Distance:
NA
Closest Genes:
CPS1 LANCL1 MYL1 ACADL KANSL1L

LLM Analysis

Numerator Metabolite Explanation:

N-acyl glycine metabolism / Fatty acid amide biosynthesis9[1], 6[2], 10[3], 11[4]

Denominator Metabolite Explanation:

Monounsaturated fatty acid biosynthesis12[1], 13[2], 14[3], 15[4], 16[5]

Ratio Explanation:

The ratio reflects a balance between fatty acid amide degradation by FAAH and de novo synthesis of monounsaturated fatty acids by SCD.13[1], 15[2], 7[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced FAAH activity increases the ratio and is linked to altered cardiovascular function and metabolic phenotypes like hypertension, myocardial infarction, and cholelithiasis.5[1], 17[2], 18[3], 8[4]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data