n-palmitoylglycine to 10-nonadecenoate (19:1n9)

Numerator Metabolite

Structure of n-palmitoylglycine
Metabolite Accession: GCST90199923
Name: n-palmitoylglycine
Hmdb Id: HMDB0013034
Super Pathway: NA
Sub Pathway: NA
Inchikey: KVTFEOAKFFQCCX

Denominator Metabolite

Structure of 10-nonadecenoate (19:1n9)
Metabolite Accession: GCST90199728
Name: 10-nonadecenoate (19:1n9)
Hmdb Id: HMDB0013622
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBOWBNGUEWHNQZ

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.359
Position:
46870761
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
23.890
Reference Allele:
C
-log10(P):
-288.770
MAF:
0.208
Beta (Num):
0.336
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.024
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs1047891

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.258
Position:
211540507
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
19.317
Reference Allele:
C
-log10(P):
-189.754
MAF:
0.310
Beta (Num):
0.247
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.011
SE (Den):
0.016
No CNV overlap
rQTL cluster:
140
Reaction Distance:
NA
Closest Genes:
CPS1 LANCL1 MYL1 ACADL KANSL1L

LLM Analysis

Numerator Metabolite Explanation:

N-acyl amino acid metabolism.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Fatty acid metabolism.10[1], 11[2], 12[3]

Ratio Explanation:

The ratio reflects FAAH activity; reduced FAAH function impairs n-palmitoylglycine degradation, increasing its levels relative to other fatty acids like 10-nonadecenoate.7[1], 13[2], 8[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced FAAH activity, indicated by an elevated ratio, dysregulates lipid and endocannabinoid signaling. This alteration of lipid metabolism and inflammation can contribute to the pathogenesis of cholelithiasis and chronic kidney disease.14[1], 15[2], 16[3]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data