2-butenoylglycine to glutamine conjugate of c7h12o2*

Numerator Metabolite

Structure of 2-butenoylglycine
Metabolite Accession: GCST90200152
Name: 2-butenoylglycine
Hmdb Id: HMDB0341232
Super Pathway: NA
Sub Pathway: NA
Inchikey: WWJXRJJBIVSSNF

Denominator Metabolite

Metabolite Accession: GCST90200167
Name: glutamine conjugate of c7h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs1047891

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.305
Position:
211540507
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
16.473
Reference Allele:
C
-log10(P):
-138.710
MAF:
0.326
Beta (Num):
0.262
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.043
SE (Den):
0.016
No CNV overlap
rQTL cluster:
140
Reaction Distance:
NA
Closest Genes:
CPS1 LANCL1 MYL1 ACADL KANSL1L

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Metabolism (Acyl Glycine)6[1], 7[2]

Denominator Metabolite Explanation:

Xenobiotic metabolism, Amino Acid Conjugation8[1], 9[2]

Ratio Explanation:

An elevated ratio may indicate increased fatty acid beta-oxidation (numerator) relative to the glutamine-dependent detoxification of xenobiotic compounds (denominator), potentially influenced by ACADL activity.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

ACADL variants impact fatty acid oxidation.1[1], 2[2], 3[3], 4[4], 5[5] Dysregulation of this process, reflected in the ratio, is linked to chronic kidney disease and cholelithiasis, possibly through altered energy metabolism and inflammatory responses.10[6], 11[7], 12[8]

Phenotype Driver:

Gene-centric:ACADL

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data