trans-2-hexenoylglycine to glutamine conjugate of c6h10o2 (1)*

Numerator Metabolite

Structure of trans-2-hexenoylglycine
Metabolite Accession: GCST90200160
Name: trans-2-hexenoylglycine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: AAPHATPOQGNLOZ

Denominator Metabolite

Metabolite Accession: GCST90200176
Name: glutamine conjugate of c6h10o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs1047891

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
2
Beta (Ratio):
0.306
Position:
211540507
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
16.793
Reference Allele:
C
-log10(P):
-144.045
MAF:
0.324
Beta (Num):
0.246
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.060
SE (Den):
0.016
No CNV overlap
rQTL cluster:
140
Reaction Distance:
NA
Closest Genes:
CPS1 LANCL1 MYL1 ACADL KANSL1L

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism (acyl glycine).6[1]

Denominator Metabolite Explanation:

Glutamine metabolism, xenobiotic detoxification.7[1], 8[2]

Ratio Explanation:

This ratio may reflect an imbalance between fatty acid oxidation and nitrogen disposal, where impaired CPS1 function could affect glutamine availability for conjugation.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Impaired CPS1 function from genetic variants can lead to hyperammonemia, a condition linked to neurological damage, and is associated with renal failure and cholelithiasis.9[1], 10[2], 11[3]

Phenotype Driver:

Gene-centric:CPS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data