n-palmitoylglycine to nonadecanoate (19:0)

Numerator Metabolite

Structure of n-palmitoylglycine
Metabolite Accession: GCST90199923
Name: n-palmitoylglycine
Hmdb Id: HMDB0013034
Super Pathway: NA
Sub Pathway: NA
Inchikey: KVTFEOAKFFQCCX

Denominator Metabolite

Structure of nonadecanoate (19:0)
Metabolite Accession: GCST90200451
Name: nonadecanoate (19:0)
Hmdb Id: HMDB0000772
Super Pathway: NA
Sub Pathway: NA
Inchikey: ISYWECDDZWTKFF

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.351
Position:
46870761
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
21.938
Reference Allele:
C
-log10(P):
-243.964
MAF:
0.208
Beta (Num):
0.336
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.015
SE (Den):
0.019
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs1047891

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.269
Position:
211540507
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
18.979
Reference Allele:
C
-log10(P):
-183.264
MAF:
0.310
Beta (Num):
0.247
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.022
SE (Den):
0.017
No CNV overlap
rQTL cluster:
140
Reaction Distance:
NA
Closest Genes:
CPS1 LANCL1 MYL1 ACADL KANSL1L

LLM Analysis

Numerator Metabolite Explanation:

N-acyl amino acid metabolism; Endocannabinoid signaling6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Fatty acid metabolism9[1], 10[2]

Ratio Explanation:

Reduced FAAH activity increases n-palmitoylglycine levels by decreasing its breakdown, while nonadecanoate levels are likely unaffected, thus elevating the ratio.11[1], 12[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced FAAH function alters endocannabinoid signaling, which is linked to inflammation and metabolic dysregulation, plausibly contributing to chronic kidney disease and cholelithiasis risk.13[1], 14[2], 15[3], 16[4], 17[5]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data