dihomo-linolenate (20:3n3 or n6) to n-palmitoylglycine

Numerator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Denominator Metabolite

Structure of n-palmitoylglycine
Metabolite Accession: GCST90199923
Name: n-palmitoylglycine
Hmdb Id: HMDB0013034
Super Pathway: NA
Sub Pathway: NA
Inchikey: KVTFEOAKFFQCCX

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.348
Position:
46870761
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-21.068
Reference Allele:
C
-log10(P):
-225.202
MAF:
0.209
Beta (Num):
-0.012
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
0.336
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs1047891

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.261
Position:
211540507
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-17.801
Reference Allele:
C
-log10(P):
-161.550
MAF:
0.310
Beta (Num):
-0.014
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.247
SE (Den):
0.016
No CNV overlap
rQTL cluster:
140
Reaction Distance:
NA
Closest Genes:
CPS1 LANCL1 MYL1 ACADL KANSL1L

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism, Biosynthesis of unsaturated fatty acids.7[1], 8[2]

Denominator Metabolite Explanation:

Fatty acid amide metabolism, Endocannabinoid signaling.3[1], 9[2], 6[3]

Ratio Explanation:

Reduced FAAH activity increases both dihomo-linolenate (via precursor sparing) and N-palmitoylglycine (a FAAH substrate), reflecting altered fatty acid amide metabolism.3[1], 10[2], 11[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced FAAH function alters fatty acid amide levels, including this ratio. This dysregulation is linked to an increased risk of cholelithiasis and chronic kidney disease, potentially through inflammatory and fibrotic pathways influenced by altered endocannabinoid signaling.12[1], 13[2], 14[3], 15[4]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data