cis 3,4-methyleneheptanoate to glycine conjugate of c10h14o2 (1)*

Numerator Metabolite

Metabolite Accession: GCST90200248
Name: cis-3,4-methyleneheptanoate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200175
Name: glycine conjugate of c10h14o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs75645849

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.403
Position:
96698970
SE (Ratio):
0.029
Effect Allele:
G
Z-score (Ratio):
-13.871
Reference Allele:
T
-log10(P):
-99.069
MAF:
0.064
Beta (Num):
-0.017
Novel Locus:
No
SE (Num):
0.032
Beta (Den):
0.386
SE (Den):
0.032
No CNV overlap
rQTL cluster:
72
Reaction Distance:
NA
Closest Genes:
CYP2C9 CYP2C19 CYP2C8 CYP2C18 C10orf129

Region: rs1047891

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.156
Position:
211540507
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-10.126
Reference Allele:
C
-log10(P):
-53.816
MAF:
0.310
Beta (Num):
-0.083
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
0.074
SE (Den):
0.017
No CNV overlap
rQTL cluster:
140
Reaction Distance:
NA
Closest Genes:
CPS1 LANCL1 MYL1 ACADL KANSL1L

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.7[1]

Denominator Metabolite Explanation:

Xenobiotic metabolism, glycine conjugation.8[1]

Ratio Explanation:

The ratio likely reflects altered CYP2C9-mediated metabolism of a precursor to the glycine conjugate, relative to cis 3,4-methyleneheptanoate, a modified fatty acid.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced CYP2C9 function can impair metabolism of endogenous compounds or xenobiotics, potentially altering bile acid composition or renal toxin clearance, thereby increasing risk for cholelithiasis and chronic kidney disease, phenotypes associated with this locus.

Phenotype Driver:

Gene-centric:CYP2C9

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data