tauro-beta-muricholate to 5alpha-androstan-3beta,17beta-diol monosulfate (2)

Numerator Metabolite

Structure of tauro-beta-muricholate
Metabolite Accession: GCST90199719
Name: tauro-beta-muricholate
Hmdb Id: HMDB0000932
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSOLDPYUICCHJX

Denominator Metabolite

Metabolite Accession: GCST90199855
Name: 5alpha-androstan-3beta,17beta-diol monosulfate (2)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
2.023
Position:
99075038
SE (Ratio):
0.075
Effect Allele:
C
Z-score (Ratio):
27.028
Reference Allele:
T
-log10(P):
-368.789
MAF:
0.050
Beta (Num):
0.932
Novel Locus:
No
SE (Num):
0.046
Beta (Den):
-1.091
SE (Den):
0.053
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

Region: rs34048349

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
1.026
Position:
100197642
SE (Ratio):
0.109
Effect Allele:
A
Z-score (Ratio):
9.407
Reference Allele:
G
-log10(P):
-46.720
MAF:
0.019
Beta (Num):
0.515
Novel Locus:
No
SE (Num):
0.074
Beta (Den):
-0.511
SE (Den):
0.070
No CNV overlap
rQTL cluster:
89
Reaction Distance:
NA
Closest Genes:
FBXO24 PCOLCE MOSPD3 LRCH4 TFR2

LLM Analysis

Numerator Metabolite Explanation:

Bile acid metabolism

Denominator Metabolite Explanation:

Androgen and steroid metabolism.3[1]

Ratio Explanation:

The ratio may reflect crosstalk between extracellular matrix regulation (PCOLCE) and steroid/bile acid pathways, although a direct enzymatic link is not established.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

PCOLCE's role in extracellular matrix organization could directly influence height and BMI.1[1], 4[2] Its documented association with steroid metabolic processes may explain links to CRP and WBC, potentially through inflammatory or signaling pathways.5[3]

Phenotype Driver:

Gene-centric:PCOLCE

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data