tauro-beta-muricholate to androstenediol (3alpha, 17alpha) monosulfate (3)

Numerator Metabolite

Structure of tauro-beta-muricholate
Metabolite Accession: GCST90199719
Name: tauro-beta-muricholate
Hmdb Id: HMDB0000932
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSOLDPYUICCHJX

Denominator Metabolite

Metabolite Accession: GCST90199856
Name: androstenediol (3alpha, 17alpha) monosulfate (3)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
1.772
Position:
99075038
SE (Ratio):
0.064
Effect Allele:
C
Z-score (Ratio):
27.634
Reference Allele:
T
-log10(P):
-385.362
MAF:
0.050
Beta (Num):
0.932
Novel Locus:
No
SE (Num):
0.046
Beta (Den):
-0.840
SE (Den):
0.037
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

Region: rs34048349

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
0.898
Position:
100197642
SE (Ratio):
0.101
Effect Allele:
A
Z-score (Ratio):
8.937
Reference Allele:
G
-log10(P):
-42.368
MAF:
0.019
Beta (Num):
0.515
Novel Locus:
No
SE (Num):
0.074
Beta (Den):
-0.383
SE (Den):
0.055
No CNV overlap
rQTL cluster:
89
Reaction Distance:
NA
Closest Genes:
FBXO24 PCOLCE MOSPD3 LRCH4 TFR2

LLM Analysis

Numerator Metabolite Explanation:

Primary bile acid biosynthesis

Denominator Metabolite Explanation:

Androgenic steroid metabolism.3[1], 4[2]

Ratio Explanation:

The ratio may reflect a trade-off between bile acid and steroid hormone production, potentially influenced by collagen metabolism. Evidence for a direct link is weak.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

PCOLCE's role in collagen synthesis1[1], 2[2] may influence tissue structure and integrity, which could be linked to phenotypes like BMI, height, and inflammatory markers through effects on bone, connective tissue, and extracellular matrix remodeling.1[3]

Phenotype Driver:

Gene-centric:PCOLCE

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data