gamma-glutamylthreonine to alanine

Numerator Metabolite

Structure of gamma-glutamylthreonine
Metabolite Accession: GCST90199749
Name: gamma-glutamylthreonine
Hmdb Id: HMDB0029159
Super Pathway: NA
Sub Pathway: NA
Inchikey: GWNXFCYUJXASDX

Denominator Metabolite

Structure of alanine
Metabolite Accession: GCST90200431
Name: alanine
Hmdb Id: HMDB0000161
Super Pathway: NA
Sub Pathway: NA
Inchikey: QNAYBMKLOCPYGJ

Associated Genomic Regions

Region: rs1260326

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.155
Position:
27730940
SE (Ratio):
0.017
Effect Allele:
T
Z-score (Ratio):
-9.105
Reference Allele:
C
-log10(P):
-43.893
MAF:
0.412
Beta (Num):
-0.106
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.049
SE (Den):
0.016
No CNV overlap
rQTL cluster:
152
Reaction Distance:
NA
Closest Genes:
GCKR FNDC4 IFT172 AC109829.1 KRTCAP3

LLM Analysis

Numerator Metabolite Explanation:

Gamma-glutamyl cycle, glutathione metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Alanine cycle, glycolysis, gluconeogenesis.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio may reflect altered liver metabolism, where gamma-glutamyl transpeptidase activity, a marker of liver stress, is modulated relative to alanine's role in gluconeogenesis.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Variants in GCKR alter hepatic glucose and lipid metabolism, which is a primary driver for the associated phenotypes of type 2 diabetes, hypercholesterolemia, and cholelithiasis; the metabolite ratio likely reflects this altered liver function.10[1], 11[2], 12[3]

Phenotype Driver:

Gene-centric:GCKR

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data