Infomap Cluster 152

Metabolite Network

mQTL individually significant in locus
Novel rQTL
Known rQTL

Aggregated Cluster Evidence

Significant GTEx eQTL Colocalization (P-alpha < 5e-5)

Tissue Gene P(alpha) Associated Metabolites
Heart Left Ventricle NFATC3 1.10e-05 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*1-palmitoyl-2-oleoyl-gpe (16:0/18:1)2r,3r-dihydroxybutyrate
Whole Blood SLC7A6 1.54e-05 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*1-palmitoyl-2-oleoyl-gpe (16:0/18:1)2r,3r-dihydroxybutyrate
Thyroid PLA2G15 3.73e-05 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*1-palmitoyl-2-oleoyl-gpe (16:0/18:1)2r,3r-dihydroxybutyrate

Genomic Context

Displaying 4 SNPs on Chr 2 for Cluster 152.

Novel rQTL (▲)
Known rQTL (▲)

Cluster Summary

65

Metabolite Ratios (rQTLs)

41

Total Unique Metabolites

6

Unnamed Metabolites

Ratios in Cluster 152

Ratio Name Novel in Cluster Driven By
1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)* to 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)* Yes
1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)* to 1-palmitoleoyl-gpc (16:1)* Yes
1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)* to 1-palmitoyl-gpe (16:0) Yes
1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)* to 1-stearoyl-gpe (18:0) Yes
1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)* to 1-oleoyl-gpc (18:1) Yes
1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)* to 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)* Yes
1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)* to 1-palmitoleoyl-gpc (16:1)* Yes
1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)* to 1-palmitoyl-gpe (16:0) Yes
1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)* to 1-stearoyl-gpe (18:0) Yes
1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)* to 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)* Yes
1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)* to 1-palmitoleoyl-gpc (16:1)* Yes
1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)* to 1-palmitoyl-gpe (16:0) Yes
1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)* to 1-stearoyl-gpe (18:0) Yes
1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)* to 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)* Yes
1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)* to 1-palmitoleoyl-gpc (16:1)* Yes
1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)* to 1-palmitoyl-gpc (16:0) Yes
1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)* to 1-palmitoyl-gpe (16:0) Yes
1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)* to 1-stearoyl-gpe (18:0) Yes
1-linolenoyl-gpc (18:3)* to 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)* Yes
1-linolenoyl-gpc (18:3)* to 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)* Yes
1-linolenoyl-gpc (18:3)* to 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)* Yes
1-linolenoyl-gpc (18:3)* to 1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)* Yes
1-linolenoyl-gpc (18:3)* to asparagine Yes
1-linolenoyl-gpc (18:3)* to gamma-glutamylthreonine No
1-linolenoyl-gpc (18:3)* to glutamine Yes
1-linolenoyl-gpc (18:3)* to threonine No
1-linolenoyl-gpc (18:3)* to x-23739 Yes N/A
1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)* to gamma-glutamylthreonine No
1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)* to glutamine Yes
1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)* to threonine No
1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)* to x-12844 Yes
1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)* to x-23739 Yes
1-palmitoleoyl-gpc (16:1)* to gamma-glutamylthreonine No
1-palmitoleoyl-gpc (16:1)* to glutamine Yes
1-palmitoleoyl-gpc (16:1)* to threonine No
1-palmitoleoyl-gpc (16:1)* to x-23739 Yes
1-palmitoyl-2-oleoyl-gpe (16:0/18:1) to 2r,3r-dihydroxybutyrate Yes
1-palmitoyl-2-oleoyl-gpe (16:0/18:1) to x-23739 Yes
1-palmitoyl-gpe (16:0) to asparagine Yes
1-palmitoyl-gpe (16:0) to gamma-glutamylthreonine No
1-palmitoyl-gpe (16:0) to glutamine Yes
1-palmitoyl-gpe (16:0) to threonine No
1-palmitoyl-gpe (16:0) to x-23739 Yes
1-stearoyl-2-linoleoyl-gpe (18:0/18:2)* to x-23739 Yes
1-stearoyl-gpe (18:0) to asparagine Yes
1-stearoyl-gpe (18:0) to gamma-glutamylthreonine No
1-stearoyl-gpe (18:0) to glutamine Yes
1-stearoyl-gpe (18:0) to threonine No
1-stearoyl-gpe (18:0) to x-23739 Yes
2-hydroxybutyrate/2-hydroxyisobutyrate to mannose No
2-hydroxybutyrate/2-hydroxyisobutyrate to x-12844 Yes
2r,3r-dihydroxybutyrate to 3-methylglutarylcarnitine (2) Yes
2r,3r-dihydroxybutyrate to x-23654 Yes
2r,3r-dihydroxybutyrate to x-24801 Yes
3-methoxytyrosine to 3-methylglutarylcarnitine (2) Yes
3-methoxytyrosine to x-21467 Yes
3-methylglutarylcarnitine (2) to gamma-glutamylthreonine No
3-methylglutarylcarnitine (2) to x-23739 Yes
gamma-glutamylthreonine to alanine No
gamma-glutamylthreonine to x-21467 No
gamma-glutamylthreonine to x-24801 No
hydroxypalmitoyl sphingomyelin (d18:1/16:0(oh))** to 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)* Yes
hydroxypalmitoyl sphingomyelin (d18:1/16:0(oh))** to 1-palmitoyl-gpe (16:0) Yes
hydroxypalmitoyl sphingomyelin (d18:1/16:0(oh))** to 1-stearoyl-gpe (18:0) Yes
lactosyl-n-nervonoyl-sphingosine (d18:1/24:1)* to 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)* Yes
lactosyl-n-nervonoyl-sphingosine (d18:1/24:1)* to 1-stearoyl-gpe (18:0) Yes
mannonate* to erythronate* No
mannonate* to x-12117 No
mannose to alpha-ketobutyrate No
oleoyl-linoleoyl-glycerol (18:1/18:2) [2] to gamma-glutamylthreonine No
oleoyl-linoleoyl-glycerol (18:1/18:2) [2] to x-12844 Yes
oleoyl-linoleoyl-glycerol (18:1/18:2) [2] to x-23739 Yes
palmitoyl sphingomyelin (d18:1/16:0) to 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)* Yes
palmitoyl sphingomyelin (d18:1/16:0) to 1-palmitoyl-gpc (16:0) Yes
palmitoyl sphingomyelin (d18:1/16:0) to 1-palmitoyl-gpe (16:0) Yes
palmitoyl sphingomyelin (d18:1/16:0) to 1-stearoyl-gpe (18:0) Yes
palmitoyl-sphingosine-phosphoethanolamine (d18:1/16:0) to 1-palmitoyl-gpe (16:0) Yes
palmitoyl-sphingosine-phosphoethanolamine (d18:1/16:0) to 1-stearoyl-gpe (18:0) Yes
pantothenate to pyridoxal Yes
sphingomyelin (d17:1/16:0, d18:1/15:0, d16:1/17:0)* to 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)* Yes
sphingomyelin (d17:1/16:0, d18:1/15:0, d16:1/17:0)* to 1-palmitoleoyl-gpc (16:1)* Yes
sphingomyelin (d17:1/16:0, d18:1/15:0, d16:1/17:0)* to 1-palmitoyl-gpe (16:0) Yes
sphingomyelin (d17:1/16:0, d18:1/15:0, d16:1/17:0)* to 1-stearoyl-gpe (18:0) Yes
x-12844 to androsterone sulfate Yes
x-12844 to x-24801 Yes