1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)* to 1-palmitoleoyl-gpc (16:1)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*
Metabolite Accession: GCST90200070
Name: 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*
Hmdb Id: HMDB0011207
Super Pathway: NA
Sub Pathway: NA
Inchikey: FZMYLOBGNYZPQO

Denominator Metabolite

Structure of 1-palmitoleoyl-gpc (16:1)*
Metabolite Accession: GCST90199777
Name: 1-palmitoleoyl-gpc (16:1)*
Hmdb Id: HMDB0010383
Super Pathway: NA
Sub Pathway: NA
Inchikey: LFUDDCMNKWEORN

Associated Genomic Regions

Region: rs1260326

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.184
Position:
27730940
SE (Ratio):
0.019
Effect Allele:
T
Z-score (Ratio):
-9.702
Reference Allele:
C
-log10(P):
-49.572
MAF:
0.414
Beta (Num):
-0.096
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
0.088
SE (Den):
0.015
No CNV overlap
rQTL cluster:
152
Reaction Distance:
NA
Closest Genes:
GCKR FNDC4 IFT172 AC109829.1 KRTCAP3

LLM Analysis

Numerator Metabolite Explanation:

Ether lipid metabolism, Plasmalogen metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Lysophospholipid metabolism.3[1]

Ratio Explanation:

The ratio reflects phospholipase activity, contrasting the abundance of an ether phospholipid (plasmalogen) with a lysophospholipid product, indicating altered phospholipid remodeling by *PLB1*.2[1], 5[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in *PLB1* likely alter its phospholipase activity, affecting the ether phospholipid to lysophospholipid balance. This dysregulation of lipid metabolism contributes to phenotypes like gout and cholelithiasis by impacting inflammatory and metabolic pathways sensitive to lipid composition.6[1], 7[2]

Phenotype Driver:

Gene-centric:PLB1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data