1-stearoyl-gpe (18:0) to glutamine

Numerator Metabolite

Structure of 1-stearoyl-gpe (18:0)
Metabolite Accession: GCST90199772
Name: 1-stearoyl-gpe (18:0)
Hmdb Id: HMDB0011130
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBYWOYAFBUOUFP

Denominator Metabolite

Structure of glutamine
Metabolite Accession: GCST90200419
Name: glutamine
Hmdb Id: HMDB0000641
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZDXPYRJPNDTMRX

Associated Genomic Regions

Region: rs1260326

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.189
Position:
27730940
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
8.966
Reference Allele:
C
-log10(P):
-42.623
MAF:
0.413
Beta (Num):
0.090
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.099
SE (Den):
0.016
No CNV overlap
rQTL cluster:
152
Reaction Distance:
NA
Closest Genes:
GCKR FNDC4 IFT172 AC109829.1 KRTCAP3

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Fatty acid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Glutamine metabolism, nucleotide and glutathione synthesis.7[1], 8[2], 9[3], 10[4], 11[5]

Ratio Explanation:

An elevated ratio may indicate a shift from glucose to lipid and amino acid metabolism, influenced by GCKR's role in regulating glucokinase activity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

GCKR variants are associated with altered glucose and lipid metabolism, influencing triglyceride levels and the risk for type 2 diabetes, gout, and cholelithiasis, which is reflected in the stearoyl-gpe to glutamine ratio, indicating a shift in substrate utilization.1[1], 2[2], 3[3], 4[4]

Phenotype Driver:

Gene-centric:GCKR

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data