1-stearoyl-gpe (18:0) to threonine

Numerator Metabolite

Structure of 1-stearoyl-gpe (18:0)
Metabolite Accession: GCST90199772
Name: 1-stearoyl-gpe (18:0)
Hmdb Id: HMDB0011130
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBYWOYAFBUOUFP

Denominator Metabolite

Structure of threonine
Metabolite Accession: GCST90200432
Name: threonine
Hmdb Id: HMDB0000167
Super Pathway: NA
Sub Pathway: NA
Inchikey: AYFVYJQAPQTCCC

Associated Genomic Regions

Region: rs1260326

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.214
Position:
27730940
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
9.892
Reference Allele:
C
-log10(P):
-51.455
MAF:
0.413
Beta (Num):
0.090
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.124
SE (Den):
0.016
No CNV overlap
rQTL cluster:
152
Reaction Distance:
NA
Closest Genes:
GCKR FNDC4 IFT172 AC109829.1 KRTCAP3

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Amino acid metabolism, Glycine, serine, and threonine metabolism.7[1], 8[2]

Ratio Explanation:

An elevated ratio, influenced by GCKR's role in hepatic lipid and glucose metabolism, may reflect altered glycerophospholipid and amino acid balance.1[1], 9[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

GCKR variants impact hepatic glucose and lipid metabolism, influencing triglyceride levels and liver fat accumulation, which are associated with cholelithiasis and type 2 diabetes.1[1], 2[2], 5[3], 10[4]

Phenotype Driver:

Gene-centric:GCKR

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data