1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)* to 1-palmitoyl-gpe (16:0)

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*
Metabolite Accession: GCST90200057
Name: 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*
Hmdb Id: HMDB0007996
Super Pathway: NA
Sub Pathway: NA
Inchikey: MPQGNHKVOVYEEN

Denominator Metabolite

Structure of 1-palmitoyl-gpe (16:0)
Metabolite Accession: GCST90199792
Name: 1-palmitoyl-gpe (16:0)
Hmdb Id: HMDB0011503
Super Pathway: NA
Sub Pathway: NA
Inchikey: YVYMBNSKXOXSKW

Associated Genomic Regions

Region: rs1260326

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
2
Beta (Ratio):
-0.177
Position:
27730940
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
-8.998
Reference Allele:
C
-log10(P):
-42.919
MAF:
0.413
Beta (Num):
-0.090
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
0.087
SE (Den):
0.016
No CNV overlap
rQTL cluster:
152
Reaction Distance:
NA
Closest Genes:
GCKR FNDC4 IFT172 AC109829.1 KRTCAP3

LLM Analysis

Numerator Metabolite Explanation:

Ether lipid metabolism, Glycerophospholipid metabolism.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

This ratio may reflect PLB1 activity, where the numerator is a substrate and the denominator a related product of glycerophospholipid degradation.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

PLB1 variants may alter glycerophospholipid metabolism, impacting the ratio of 1-(1-enyl-palmitoyl)-2-oleoyl-gpc to 1-palmitoyl-gpe. This dysregulation is linked to an increased risk for cholelithiasis and type 2 diabetes, likely through altered lipid signaling and membrane composition affecting metabolic and inflammatory pathways.1[1], 2[2], 9[3], 10[4]

Phenotype Driver:

Gene-centric:PLB1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data