mannonate* to erythronate*

Numerator Metabolite

Structure of mannonate*
Metabolite Accession: GCST90199932
Name: mannonate*
Hmdb Id: HMDB0242119
Super Pathway: NA
Sub Pathway: NA
Inchikey: RGHNJXZEOKUKBD

Denominator Metabolite

Structure of erythronate*
Metabolite Accession: GCST90199746
Name: erythronate*
Hmdb Id: HMDB0000613
Super Pathway: NA
Sub Pathway: NA
Inchikey: JPIJQSOTBSSVTP

Associated Genomic Regions

Region: rs1260326

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.258
Position:
27730940
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
-15.733
Reference Allele:
C
-log10(P):
-126.746
MAF:
0.413
Beta (Num):
-0.211
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.046
SE (Den):
0.014
No CNV overlap
rQTL cluster:
152
Reaction Distance:
NA
Closest Genes:
GCKR FNDC4 IFT172 AC109829.1 KRTCAP3

LLM Analysis

Numerator Metabolite Explanation:

Pentose and glucuronate interconversions.10[1], 11[2], 12[3], 13[4], 14[5]

Denominator Metabolite Explanation:

Pentose phosphate pathway.15[1], 16[2], 17[3]

Ratio Explanation:

The ratio may reflect the balance between uronic acid and pentose phosphate pathway flux, which is modulated by GCKR's control over glucose utilization.1[1], 2[2], 15[3], 10[4], 5[5]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

GCKR variants impact glucokinase activity, altering glucose flux into glycolysis and connected pathways like the uronic acid and pentose phosphate pathways, affecting the ratio.1[1], 2[2], 5[3] This genetic predisposition is linked to phenotypes like gout, T2D, and dyslipidemia, which are strongly associated with GCKR.3[4], 4[5], 7[6], 8[7], 9[8]

Phenotype Driver:

Gene-centric:GCKR

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data