1-stearoyl-gpe (18:0) to gamma-glutamylthreonine

Numerator Metabolite

Structure of 1-stearoyl-gpe (18:0)
Metabolite Accession: GCST90199772
Name: 1-stearoyl-gpe (18:0)
Hmdb Id: HMDB0011130
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBYWOYAFBUOUFP

Denominator Metabolite

Structure of gamma-glutamylthreonine
Metabolite Accession: GCST90199749
Name: gamma-glutamylthreonine
Hmdb Id: HMDB0029159
Super Pathway: NA
Sub Pathway: NA
Inchikey: GWNXFCYUJXASDX

Associated Genomic Regions

Region: rs1260326

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.197
Position:
27730940
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
9.110
Reference Allele:
C
-log10(P):
-43.945
MAF:
0.413
Beta (Num):
0.090
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.106
SE (Den):
0.016
No CNV overlap
rQTL cluster:
152
Reaction Distance:
NA
Closest Genes:
GCKR FNDC4 IFT172 AC109829.1 KRTCAP3

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylethanolamine (PE) metabolism, glycerophospholipid metabolism.5[1]

Denominator Metabolite Explanation:

Gamma-glutamyl cycle, glutathione metabolism.6[1], 7[2]

Ratio Explanation:

The ratio may reflect the interplay between lipid metabolism (numerator) and the gamma-glutamyl cycle (denominator), with GCKR potentially influencing both, though direct evidence is weak.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

GCKR variants are linked to altered glucose and lipid metabolism, increasing susceptibility to phenotypes like type 2 diabetes, cholelithiasis, and gout.1[1], 3[2], 8[3], 9[4], 10[5] The ratio of 1-stearoyl-gpe (18:0) to gamma-glutamylthreonine may represent a metabolic signature of these GCKR-driven alterations.

Phenotype Driver:

Gene-centric:GCKR

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data