oleoyl-linoleoyl-glycerol (18:1/18:2) [2] to gamma-glutamylthreonine

Numerator Metabolite

Structure of oleoyl-linoleoyl-glycerol (18:1/18:2) [2]
Metabolite Accession: GCST90199914
Name: oleoyl-linoleoyl-glycerol (18:1/18:2) [2]
Hmdb Id: HMDB0007219
Super Pathway: NA
Sub Pathway: NA
Inchikey: BLZVZPYMHLXLHG

Denominator Metabolite

Structure of gamma-glutamylthreonine
Metabolite Accession: GCST90199749
Name: gamma-glutamylthreonine
Hmdb Id: HMDB0029159
Super Pathway: NA
Sub Pathway: NA
Inchikey: GWNXFCYUJXASDX

Associated Genomic Regions

Region: rs4665972

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
2
Beta (Ratio):
0.201
Position:
27598097
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
8.814
Reference Allele:
C
-log10(P):
-41.256
MAF:
0.410
Beta (Num):
0.095
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.106
SE (Den):
0.016
No CNV overlap
rQTL cluster:
152
Reaction Distance:
NA
Closest Genes:
SNX17 ZNF513 EIF2B4 PPM1G GTF3C2

LLM Analysis

Numerator Metabolite Explanation:

Glycerolipid metabolism, Triglyceride biosynthesis.3[1]

Denominator Metabolite Explanation:

Gamma-glutamyl cycle, Glutathione metabolism.1[1], 4[2]

Ratio Explanation:

The ratio reflects a balance between glycerolipid synthesis and gamma-glutamyl cycle activity. ATRAID's role in lipid metabolism and interaction with GGT1 may mediate this balance.1[1], 2[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in ATRAID likely dysregulate lipid metabolism and the gamma-glutamyl cycle, altering this ratio. This metabolic state is associated with phenotypes like liver disease (cirrhosis), dyslipidemia, and heart disease, consistent with ATRAID's known functions.2[1], 5[2], 6[3], 7[4]

Phenotype Driver:

Gene-centric:ATRAID

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data