1-linolenoyl-gpc (18:3)* to glutamine

Numerator Metabolite

Structure of 1-linolenoyl-gpc (18:3)*
Metabolite Accession: GCST90199958
Name: 1-linolenoyl-gpc (18:3)*
Hmdb Id: HMDB0010388
Super Pathway: NA
Sub Pathway: NA
Inchikey: WKQNRCYKYCKESD

Denominator Metabolite

Structure of glutamine
Metabolite Accession: GCST90200419
Name: glutamine
Hmdb Id: HMDB0000641
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZDXPYRJPNDTMRX

Associated Genomic Regions

Region: rs1260326

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.183
Position:
27730940
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
8.733
Reference Allele:
C
-log10(P):
-40.540
MAF:
0.413
Beta (Num):
0.084
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.099
SE (Den):
0.016
No CNV overlap
rQTL cluster:
152
Reaction Distance:
NA
Closest Genes:
GCKR FNDC4 IFT172 AC109829.1 KRTCAP3

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Lysophospholipid metabolism.5[1]

Denominator Metabolite Explanation:

Glutamine metabolism, Amino acid metabolism, Glutaminolysis.6[1], 7[2], 8[3]

Ratio Explanation:

This ratio may reflect the balance between hepatic lipid (lysophosphatidylcholine) and amino acid metabolism, which is influenced by GCKR's central role in regulating glucose flux.1[1], 9[2], 10[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

GCKR variants alter hepatic glucose sensing, which affects downstream lipogenesis and amino acid utilization, thereby changing the 1-linolenoyl-gpc to glutamine ratio.1[1], 9[2], 10[3] This metabolic dysregulation is strongly linked to phenotypes like Type 2 diabetes, hypercholesterolemia, and cholelithiasis.1[4], 11[5], 12[6]

Phenotype Driver:

Gene-centric:GCKR

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data