1-palmitoleoyl-gpc (16:1)* to glutamine

Numerator Metabolite

Structure of 1-palmitoleoyl-gpc (16:1)*
Metabolite Accession: GCST90199777
Name: 1-palmitoleoyl-gpc (16:1)*
Hmdb Id: HMDB0010383
Super Pathway: NA
Sub Pathway: NA
Inchikey: LFUDDCMNKWEORN

Denominator Metabolite

Structure of glutamine
Metabolite Accession: GCST90200419
Name: glutamine
Hmdb Id: HMDB0000641
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZDXPYRJPNDTMRX

Associated Genomic Regions

Region: rs1260326

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.187
Position:
27730940
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
8.637
Reference Allele:
C
-log10(P):
-39.692
MAF:
0.413
Beta (Num):
0.088
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.099
SE (Den):
0.016
No CNV overlap
rQTL cluster:
152
Reaction Distance:
NA
Closest Genes:
GCKR FNDC4 IFT172 AC109829.1 KRTCAP3

LLM Analysis

Numerator Metabolite Explanation:

Phospholipid biosynthesis, Glycerophospholipid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Glutaminolysis, amino acid and nucleotide metabolism.7[1], 8[2], 9[3], 10[4]

Ratio Explanation:

The ratio may reflect the interplay between lipid synthesis and amino acid catabolism, potentially influenced by hepatic glucose and lipid regulation via GCKR.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

GCKR variants are associated with altered triglyceride and glucose levels, which can influence both phospholipid metabolism and glutamine utilization, contributing to the risk of type 2 diabetes, non-alcoholic fatty liver disease, and cardiovascular disease seen in PheWAS.1[1], 2[2], 11[3]

Phenotype Driver:

Gene-centric:GCKR

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data