1-palmitoyl-gpe (16:0) to gamma-glutamylthreonine

Numerator Metabolite

Structure of 1-palmitoyl-gpe (16:0)
Metabolite Accession: GCST90199792
Name: 1-palmitoyl-gpe (16:0)
Hmdb Id: HMDB0011503
Super Pathway: NA
Sub Pathway: NA
Inchikey: YVYMBNSKXOXSKW

Denominator Metabolite

Structure of gamma-glutamylthreonine
Metabolite Accession: GCST90199749
Name: gamma-glutamylthreonine
Hmdb Id: HMDB0029159
Super Pathway: NA
Sub Pathway: NA
Inchikey: GWNXFCYUJXASDX

Associated Genomic Regions

Region: rs1260326

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.193
Position:
27730940
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
9.032
Reference Allele:
C
-log10(P):
-43.229
MAF:
0.412
Beta (Num):
0.087
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.106
SE (Den):
0.016
No CNV overlap
rQTL cluster:
152
Reaction Distance:
NA
Closest Genes:
GCKR FNDC4 IFT172 AC109829.1 KRTCAP3

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Fatty Acid Metabolism3[1], 4[2]

Denominator Metabolite Explanation:

Glutathione metabolism, Gamma-glutamyl cycle5[1]

Ratio Explanation:

The ratio likely reflects a balance between glycerophospholipid breakdown by PLB1 and gamma-glutamyl amino acid metabolism.1[1], 5[2], 3[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in PLB1 may alter its phospholipase activity, affecting 1-palmitoyl-gpe levels. This dysregulation of lipid metabolism is linked to metabolic phenotypes like Type 2 diabetes and Cholelithiasis, which are associated with this locus.2[1], 6[2], 7[3]

Phenotype Driver:

Gene-centric:PLB1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data