1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)* to 1-stearoyl-gpe (18:0)

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)*
Metabolite Accession: GCST90200060
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)*
Hmdb Id: HMDB0011211
Super Pathway: NA
Sub Pathway: NA
Inchikey: QLEHHUPUHJPURI

Denominator Metabolite

Structure of 1-stearoyl-gpe (18:0)
Metabolite Accession: GCST90199772
Name: 1-stearoyl-gpe (18:0)
Hmdb Id: HMDB0011130
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBYWOYAFBUOUFP

Associated Genomic Regions

Region: rs1260326

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.177
Position:
27730940
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
-8.674
Reference Allele:
C
-log10(P):
-40.019
MAF:
0.412
Beta (Num):
-0.087
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
0.090
SE (Den):
0.015
No CNV overlap
rQTL cluster:
152
Reaction Distance:
NA
Closest Genes:
GCKR FNDC4 IFT172 AC109829.1 KRTCAP3

LLM Analysis

Numerator Metabolite Explanation:

Ether lipid metabolism, Glycerophospholipid metabolism.4[1], 5[2], 6[3], 7[4]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Lysophospholipid metabolism.8[1], 9[2]

Ratio Explanation:

This ratio contrasts a stable membrane ether phospholipid (numerator) with a signaling lysophospholipid (denominator), potentially reflecting PLB1-mediated membrane remodeling and signaling molecule generation.1[1], 10[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in PLB1, an eQTL for this ratio, alters phospholipase activity.1[1] This disrupts glycerophospholipid metabolism, impacting membrane composition and signaling, which contributes to phenotypes like cholelithiasis and type 2 diabetes.11[2], 12[3], 13[4], 14[5], 15[6], 16[7], 17[8]

Phenotype Driver:

Gene-centric:PLB1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data