1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)* to 1-oleoyl-gpc (18:1)

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*
Metabolite Accession: GCST90200057
Name: 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*
Hmdb Id: HMDB0007996
Super Pathway: NA
Sub Pathway: NA
Inchikey: MPQGNHKVOVYEEN

Denominator Metabolite

Structure of 1-oleoyl-gpc (18:1)
Metabolite Accession: GCST90199727
Name: 1-oleoyl-gpc (18:1)
Hmdb Id: HMDB0002815
Super Pathway: NA
Sub Pathway: NA
Inchikey: YAMUFBLWGFFICM

Associated Genomic Regions

Region: rs1260326

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.142
Position:
27730940
SE (Ratio):
0.017
Effect Allele:
T
Z-score (Ratio):
-8.561
Reference Allele:
C
-log10(P):
-39.031
MAF:
0.413
Beta (Num):
-0.090
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
0.052
SE (Den):
0.016
No CNV overlap
rQTL cluster:
152
Reaction Distance:
NA
Closest Genes:
GCKR FNDC4 IFT172 AC109829.1 KRTCAP3

LLM Analysis

Numerator Metabolite Explanation:

Ether lipid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.6[1]

Ratio Explanation:

The ratio may reflect PLB1 activity, where higher values suggest reduced hydrolysis of the ether lipid numerator relative to the lyso-lipid denominator pool.1[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants near PLB1 colocalize with this ratio. Altered PLB1 function likely disrupts glycerophospholipid metabolism, contributing to inflammation and metabolic dysfunction underlying phenotypes like gout, cholelithiasis, and type 2 diabetes.8[1], 9[2], 10[3], 11[4]

Phenotype Driver:

Gene-centric:[PLB1]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data