epiandrosterone sulfate to androsterone glucuronide

Numerator Metabolite

Structure of epiandrosterone sulfate
Metabolite Accession: GCST90199752
Name: epiandrosterone sulfate
Hmdb Id: HMDB0062657
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs62129966

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.225
Position:
48374950
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
-11.556
Reference Allele:
C
-log10(P):
-69.446
MAF:
0.162
Beta (Num):
-0.055
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.170
SE (Den):
0.018
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

Region: rs969114

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Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
0.147
Position:
69338311
SE (Ratio):
0.015
Effect Allele:
G
Z-score (Ratio):
9.941
Reference Allele:
A
-log10(P):
-51.945
MAF:
0.409
Beta (Num):
0.096
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.051
SE (Den):
0.014
No CNV overlap
rQTL cluster:
124
Reaction Distance:
NA
Closest Genes:
TMPRSS11E UGT2B17 YTHDC1 UGT2B15 TMPRSS11B

LLM Analysis

Numerator Metabolite Explanation:

Androgen metabolism, Steroid sulfation5[1], 6[2]

Denominator Metabolite Explanation:

Androgen metabolism, Steroid glucuronidation7[1], 8[2], 9[3]

Ratio Explanation:

This ratio reflects competing androgen inactivation pathways: sulfation (epiandrosterone sulfate) by SULTs versus glucuronidation (androsterone glucuronide) by UGTs like UGT2B15/UGT2B17.7[1], 9[2], 2[3], 4[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic evidence suggests altered SULT2A1 activity, which influences the balance of steroid and bile acid metabolism.1[1], 3[2], 10[3] This dysregulation is linked to an increased risk of cholelithiasis (gallstones) and disorders of lipoprotein metabolism.10[4], 11[5], 12[6]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data