Infomap Cluster 7

Metabolite Network

mQTL individually significant in locus
Novel rQTL
Known rQTL

Aggregated Cluster Evidence

Significant GTEx eQTL Colocalization (P-alpha < 5e-5)

Tissue Gene P(alpha) Associated Metabolites
Heart Left Ventricle NFATC3 1.10e-05 5alpha-pregnan-3beta,20alpha-diol disulfateandrosterone glucuronide
Whole Blood SLC7A6 1.54e-05 5alpha-pregnan-3beta,20alpha-diol disulfateandrosterone glucuronide
Thyroid PLA2G15 3.73e-05 5alpha-pregnan-3beta,20alpha-diol disulfateandrosterone glucuronide

Genomic Context

Displaying 8 SNPs on Chr 19 for Cluster 7.

Novel rQTL (▲)
Known rQTL (▲)

Cluster Summary

115

Metabolite Ratios (rQTLs)

53

Total Unique Metabolites

11

Unnamed Metabolites

Ratios in Cluster 7

Ratio Name Novel in Cluster Driven By
21-hydroxypregnenolone disulfate to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) No
21-hydroxypregnenolone disulfate to androsterone glucuronide No
3b-hydroxy-5-cholenoic acid to 21-hydroxypregnenolone disulfate No
3b-hydroxy-5-cholenoic acid to 5alpha-androstan-3alpha,17beta-diol monosulfate (1) No
3b-hydroxy-5-cholenoic acid to 5alpha-androstan-3beta,17alpha-diol disulfate No
3b-hydroxy-5-cholenoic acid to 5alpha-pregnan-diol disulfate No
3b-hydroxy-5-cholenoic acid to androsterone sulfate No
3b-hydroxy-5-cholenoic acid to glycocholate glucuronide (1) No
3b-hydroxy-5-cholenoic acid to pregnenediol sulfate (c21h34o5s)* No
3b-hydroxy-5-cholenoic acid to x-12851 No
3b-hydroxy-5-cholenoic acid to x-22520 No
3b-hydroxy-5-cholenoic acid to x-24546 No
3b-hydroxy-5-cholenoic acid to x-24947 No
3b-hydroxy-5-cholenoic acid to x-26109 No
5alpha-androstan-3alpha,17beta-diol monosulfate (1) to androsterone glucuronide No
5alpha-androstan-3alpha,17beta-diol monosulfate (2) to 21-hydroxypregnenolone disulfate No
5alpha-androstan-3alpha,17beta-diol monosulfate (2) to 5alpha-androstan-3alpha,17beta-diol monosulfate (1) No
5alpha-androstan-3alpha,17beta-diol monosulfate (2) to 5alpha-androstan-3beta,17alpha-diol disulfate No
5alpha-androstan-3alpha,17beta-diol monosulfate (2) to androstenediol (3alpha, 17alpha) monosulfate (3) No
5alpha-androstan-3alpha,17beta-diol monosulfate (2) to pregnenediol sulfate (c21h34o5s)* No
5alpha-androstan-3alpha,17beta-diol monosulfate (2) to x-21441 No
5alpha-androstan-3alpha,17beta-diol monosulfate (2) to x-21470 No
5alpha-androstan-3alpha,17beta-diol monosulfate (2) to x-21471 No
5alpha-androstan-3alpha,17beta-diol monosulfate (2) to x-24947 No
5alpha-androstan-3beta,17alpha-diol disulfate to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) No
5alpha-androstan-3beta,17alpha-diol disulfate to androsterone glucuronide No
5alpha-androstan-3beta,17beta-diol disulfate to 3b-hydroxy-5-cholenoic acid No
5alpha-androstan-3beta,17beta-diol disulfate to 5alpha-androstan-3alpha,17beta-diol monosulfate (2) No
5alpha-androstan-3beta,17beta-diol disulfate to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) No
5alpha-androstan-3beta,17beta-diol disulfate to androsterone glucuronide No
5alpha-androstan-3beta,17beta-diol disulfate to pregnanediol-3-glucuronide No
5alpha-androstan-3beta,17beta-diol disulfate to x-21442 No
5alpha-androstan-3beta,17beta-diol monosulfate (2) to androsterone glucuronide No
5alpha-pregnan-3beta,20alpha-diol disulfate to 3b-hydroxy-5-cholenoic acid No
5alpha-pregnan-3beta,20alpha-diol disulfate to 5alpha-androstan-3alpha,17beta-diol monosulfate (2) No
5alpha-pregnan-3beta,20alpha-diol disulfate to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) No
5alpha-pregnan-3beta,20alpha-diol disulfate to androsterone glucuronide No
5alpha-pregnan-3beta,20alpha-diol disulfate to pregnanediol-3-glucuronide No
5alpha-pregnan-3beta,20alpha-diol monosulfate (2) to 5alpha-androstan-3alpha,17beta-diol monosulfate (1) No
5alpha-pregnan-3beta,20alpha-diol monosulfate (2) to 5alpha-androstan-3beta,17beta-diol monosulfate (2) No
5alpha-pregnan-3beta,20alpha-diol monosulfate (2) to 5alpha-pregnan-diol disulfate No
5alpha-pregnan-3beta,20alpha-diol monosulfate (2) to androstenediol (3alpha, 17alpha) monosulfate (3) No
5alpha-pregnan-3beta,20alpha-diol monosulfate (2) to androsterone sulfate No
5alpha-pregnan-3beta,20alpha-diol monosulfate (2) to DHEAS No
5alpha-pregnan-3beta,20alpha-diol monosulfate (2) to epiandrosterone sulfate No
5alpha-pregnan-3beta,20alpha-diol monosulfate (2) to pregnenediol sulfate (c21h34o5s)* No
5alpha-pregnan-3beta,20alpha-diol monosulfate (2) to x-21470 No
5alpha-pregnan-3beta,20alpha-diol monosulfate (2) to x-22520 No
5alpha-pregnan-3beta,20alpha-diol monosulfate (2) to x-24544 No
5alpha-pregnan-3beta,20alpha-diol monosulfate (2) to x-24546 No
5alpha-pregnan-3beta,20alpha-diol monosulfate (2) to x-24947 No
5alpha-pregnan-3beta,20alpha-diol monosulfate (2) to x-26109 No
5alpha-pregnan-3beta,20beta-diol monosulfate (1) to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) No
andro steroid monosulfate c19h28o6s (1)* to x-21470 No
androstenediol (3alpha, 17alpha) monosulfate (3) to androsterone glucuronide No
androstenediol (3beta,17beta) disulfate (1) to 5alpha-androstan-3alpha,17beta-diol monosulfate (2) No
androstenediol (3beta,17beta) disulfate (1) to androstenediol (3beta,17beta) disulfate (2) No
androstenediol (3beta,17beta) disulfate (1) to androstenediol (3beta,17beta) monosulfate (1) No
androstenediol (3beta,17beta) disulfate (1) to androstenediol (3beta,17beta) monosulfate (2) No
androstenediol (3beta,17beta) disulfate (1) to androsterone glucuronide No
androstenediol (3beta,17beta) disulfate (2) to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) No
androstenediol (3beta,17beta) disulfate (2) to androsterone glucuronide No
androstenediol (3beta,17beta) disulfate (2) to x-21470 No
androstenediol (3beta,17beta) monosulfate (1) to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) No
androstenediol (3beta,17beta) monosulfate (1) to androsterone glucuronide No
androstenediol (3beta,17beta) monosulfate (1) to pregnanediol-3-glucuronide Yes
androstenediol (3beta,17beta) monosulfate (2) to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) No
androstenediol (3beta,17beta) monosulfate (2) to androsterone glucuronide No
androstenediol (3beta,17beta) monosulfate (2) to pregnanediol-3-glucuronide Yes
androsterone glucuronide to androsterone sulfate No
androsterone glucuronide to DHEAS No
androsterone glucuronide to x-21470 No
androsterone glucuronide to x-24544 No
androsterone glucuronide to x-24546 No
androsterone glucuronide to x-24947 No
androsterone glucuronide to x-26109 No
deoxycholic acid 12-sulfate* to 3b-hydroxy-5-cholenoic acid No
deoxycholic acid 12-sulfate* to 5alpha-androstan-3alpha,17beta-diol monosulfate (2) No
deoxycholic acid 12-sulfate* to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) No
deoxycholic acid 12-sulfate* to androsterone glucuronide No
deoxycholic acid 12-sulfate* to glycolithocholate No
epiandrosterone sulfate to androsterone glucuronide No
epiandrosterone sulfate to androsterone sulfate Yes
etiocholanolone glucuronide to 21-hydroxypregnenolone disulfate No
etiocholanolone glucuronide to DHEAS Yes
glycochenodeoxycholate 3-sulfate to 5alpha-androstan-3alpha,17beta-diol monosulfate (2) No
glycochenodeoxycholate 3-sulfate to androsterone glucuronide No
glycochenodeoxycholate 3-sulfate to glycohyocholate No
glycodeoxycholate 3-sulfate to 3b-hydroxy-5-cholenoic acid No
glycodeoxycholate 3-sulfate to 5alpha-androstan-3alpha,17beta-diol monosulfate (2) No
glycodeoxycholate 3-sulfate to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) No
glycodeoxycholate 3-sulfate to androsterone glucuronide No
glycodeoxycholate 3-sulfate to glyco-beta-muricholate** No
glycodeoxycholate 3-sulfate to glycochenodeoxycholate glucuronide (1) No
glycolithocholate sulfate* to glycolithocholate Yes
glycolithocholate to x-22520 Yes
glycoursodeoxycholic acid sulfate (1) to 3b-hydroxy-5-cholenoic acid No
glycoursodeoxycholic acid sulfate (1) to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) No
glycoursodeoxycholic acid sulfate (1) to androsterone glucuronide No
lithocholate sulfate (1) to 3b-hydroxy-5-cholenoic acid No
lithocholate sulfate (1) to 5alpha-androstan-3alpha,17beta-diol monosulfate (2) No
lithocholate sulfate (1) to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) No
lithocholate sulfate (1) to androsterone glucuronide No
lithocholate sulfate (1) to glycolithocholate No
lithocholate sulfate (1) to pregnanediol-3-glucuronide No
metabolonic lactone sulfate to 3b-hydroxy-5-cholenoic acid No
metabolonic lactone sulfate to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) No
metabolonic lactone sulfate to androsterone glucuronide No
pregnanediol-3-glucuronide to 21-hydroxypregnenolone disulfate No
pregnanediol-3-glucuronide to 5alpha-androstan-3alpha,17beta-diol monosulfate (1) No
pregnanediol-3-glucuronide to 5alpha-androstan-3beta,17alpha-diol disulfate No
pregnanediol-3-glucuronide to 5alpha-pregnan-3beta,20beta-diol monosulfate (1) Yes
pregnanediol-3-glucuronide to 5alpha-pregnan-diol disulfate Yes
pregnanediol-3-glucuronide to androstenediol (3beta,17beta) disulfate (2) Yes
pregnanediol-3-glucuronide to androsterone sulfate Yes
pregnanediol-3-glucuronide to DHEAS Yes
pregnanediol-3-glucuronide to pregnenediol sulfate (c21h34o5s)* No
pregnanediol-3-glucuronide to x-21441 No
pregnanediol-3-glucuronide to x-21470 No Denominator
pregnanediol-3-glucuronide to x-22520 Yes
pregnanediol-3-glucuronide to x-24546 No
pregnanediol-3-glucuronide to x-24947 No
pregnenediol disulfate (c21h34o8s2)* to 5alpha-androstan-3alpha,17beta-diol monosulfate (2) No
pregnenediol disulfate (c21h34o8s2)* to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) No
pregnenediol disulfate (c21h34o8s2)* to androstenediol (3beta,17beta) disulfate (2) No
pregnenediol disulfate (c21h34o8s2)* to androsterone glucuronide No
pregnenediol disulfate (c21h34o8s2)* to pregnenediol sulfate (c21h34o5s)* No
pregnenediol sulfate (c21h34o5s)* to androsterone glucuronide No
pregnenetriol disulfate* to 5alpha-androstan-3alpha,17beta-diol monosulfate (2) No
pregnenetriol disulfate* to androstenediol (3beta,17beta) disulfate (2) No
pregnenetriol disulfate* to androsterone glucuronide No
pregnenetriol disulfate* to x-21364 No
pregnenetriol sulfate* to 5alpha-androstan-3alpha,17beta-diol monosulfate (2) No
pregnenetriol sulfate* to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) No
pregnenetriol sulfate* to androsterone glucuronide No
pregnenetriol sulfate* to pregnanediol-3-glucuronide No
pregnenolone sulfate to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) No
pregnenolone sulfate to androsterone glucuronide No
pregnenolone sulfate to pregnanediol-3-glucuronide Yes
taurochenodeoxycholic acid 3-sulfate to 3b-hydroxy-5-cholenoic acid No
taurochenodeoxycholic acid 3-sulfate to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) No
taurochenodeoxycholic acid 3-sulfate to androsterone glucuronide No
taurochenodeoxycholic acid 3-sulfate to x-21442 No
taurodeoxycholic acid 3-sulfate to 3b-hydroxy-5-cholenoic acid No
taurodeoxycholic acid 3-sulfate to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) No
taurodeoxycholic acid 3-sulfate to pregnanediol-3-glucuronide Yes
taurodeoxycholic acid 3-sulfate to x-21442 Yes
x-21364 to 21-hydroxypregnenolone disulfate No
x-21364 to x-21470 No
x-21441 to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) No
x-21441 to androsterone glucuronide No
x-21442 to 21-hydroxypregnenolone disulfate No
x-21442 to 5alpha-androstan-3beta,17alpha-diol disulfate No
x-21442 to 5alpha-pregnan-diol disulfate Yes
x-21442 to androsterone sulfate Yes
x-21442 to pregnenediol sulfate (c21h34o5s)* No
x-21442 to x-22520 Yes
x-21442 to x-24546 No
x-21442 to x-24947 No
x-21471 to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2) No
x-21471 to androsterone glucuronide No