glycochenodeoxycholate 3-sulfate to glycohyocholate

Numerator Metabolite

Structure of glycochenodeoxycholate 3-sulfate
Metabolite Accession: GCST90200022
Name: glycochenodeoxycholate 3-sulfate
Hmdb Id: HMDB0002409,HMDB0002497
Super Pathway: NA
Sub Pathway: NA
Inchikey: DKXXSIJHWWVNMO

Denominator Metabolite

Structure of glycohyocholate
Metabolite Accession: GCST90199935
Name: glycohyocholate
Hmdb Id: HMDB0000138
Super Pathway: NA
Sub Pathway: NA
Inchikey: RFDAIACWWDREDC

Associated Genomic Regions

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.347
Position:
48374950
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
-15.945
Reference Allele:
C
-log10(P):
-130.123
MAF:
0.160
Beta (Num):
-0.303
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.044
SE (Den):
0.022
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Bile acid sulfation / metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Primary/secondary bile acid metabolism.7[1], 8[2]

Ratio Explanation:

This ratio reflects SULT2A1 activity, comparing a sulfated, detoxified bile acid (numerator) to another bile acid (denominator) in the overall metabolic pool.1[1], 4[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in SULT2A1 alter its function, modifying bile acid composition, which is reflected in the ratio.9[1], 10[2], 11[3] This dysregulation is a known risk factor for cholelithiasis (gallstones), a phenotype strongly associated with this gene and metabolic ratio.12[4], 13[5], 9[6], 10[7]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data