androstenediol (3beta,17beta) disulfate (1) to androstenediol (3beta,17beta) monosulfate (1)

Numerator Metabolite

Structure of androstenediol (3beta,17beta) disulfate (1)
Metabolite Accession: GCST90199842
Name: androstenediol (3beta,17beta) disulfate (1)
Hmdb Id: HMDB0240313
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWPTUYJASNIIJM

Denominator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (1)
Metabolite Accession: GCST90199872
Name: androstenediol (3beta,17beta) monosulfate (1)
Hmdb Id: HMDB0240429
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Associated Genomic Regions

Region: rs55672373

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.160
Position:
101594853
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
-8.160
Reference Allele:
C
-log10(P):
-35.630
MAF:
0.059
Beta (Num):
-0.105
Novel Locus:
Yes ✔️
SE (Num):
0.030
Beta (Den):
0.055
SE (Den):
0.029
No CNV overlap
rQTL cluster:
68
Reaction Distance:
NA
Closest Genes:
ABCC2 DNMBP CUTC COX15 ENTPD7

Region: rs62129966

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.318
Position:
48374950
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
-25.570
Reference Allele:
C
-log10(P):
-330.387
MAF:
0.160
Beta (Num):
-0.399
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.081
SE (Den):
0.018
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Androgen and estrogen metabolism.4[1], 5[2]

Ratio Explanation:

This ratio reflects the sulfation activity of SULT2A1, converting androstenediol monosulfate to disulfate, a step in steroid hormone metabolism.6[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced SULT2A1 activity may alter androstenediol sulfate levels, and SULT2A1 is genetically associated with cholelithiasis and affects levels of liver enzymes also associated with biliary disease.8[1], 9[2], 10[3], 11[4], 12[5], 13[6], 14[7]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data