androstenediol (3beta,17beta) disulfate (1) to 5alpha-androstan-3alpha,17beta-diol monosulfate (2)

Numerator Metabolite

Structure of androstenediol (3beta,17beta) disulfate (1)
Metabolite Accession: GCST90199842
Name: androstenediol (3beta,17beta) disulfate (1)
Hmdb Id: HMDB0240313
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWPTUYJASNIIJM

Denominator Metabolite

Metabolite Accession: GCST90199983
Name: 5alpha-androstan-3alpha,17beta-diol monosulfate (2)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs62129966

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.647
Position:
48374950
SE (Ratio):
0.024
Effect Allele:
A
Z-score (Ratio):
-26.995
Reference Allele:
C
-log10(P):
-367.890
MAF:
0.160
Beta (Num):
-0.399
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.248
SE (Den):
0.017
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen metabolism

Denominator Metabolite Explanation:

Androgen and estrogen metabolism

Ratio Explanation:

The ratio reflects SULT2A1 activity, where higher values suggest increased sulfation of androstenediol relative to the formation of 5alpha-androstan-3alpha,17beta-diol monosulfate.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in SULT2A1 are associated with altered sulfation of steroids and bile acids.3[1], 4[2] This altered metabolism is linked to an increased risk of cholelithiasis, likely due to changes in bile acid composition and solubility.3[3], 4[4], 5[5]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data