deoxycholic acid 12-sulfate* to glycolithocholate

Numerator Metabolite

Metabolite Accession: GCST90200250
Name: deoxycholic acid 12-sulfate*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of glycolithocholate
Metabolite Accession: GCST90199689
Name: glycolithocholate
Hmdb Id: HMDB00698
Super Pathway: NA
Sub Pathway: NA
Inchikey: XBSQTYHEGZTYJE

Associated Genomic Regions

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.319
Position:
48374950
SE (Ratio):
0.028
Effect Allele:
A
Z-score (Ratio):
-11.595
Reference Allele:
C
-log10(P):
-69.900
MAF:
0.156
Beta (Num):
-0.209
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
0.110
SE (Den):
0.022
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Secondary bile acid metabolism, sulfation.3[1], 4[2]

Denominator Metabolite Explanation:

Secondary bile acid metabolism, conjugation.5[1], 6[2]

Ratio Explanation:

This ratio reflects the activity of SULT2A1-mediated sulfation of deoxycholic acid versus glycine conjugation of lithocholic acid, two key detoxification pathways for secondary bile acids.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced SULT2A1 activity, indicated by a lower ratio, impairs bile acid sulfation.3[1], 7[2] This alters bile composition, increasing the risk of cholesterol precipitation and the formation of gallstones (Cholelithiasis) and subsequent gallbladder inflammation (Cholecystitis).8[3], 9[4], 10[5]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data