etiocholanolone glucuronide to DHEAS

Numerator Metabolite

Structure of etiocholanolone glucuronide
Metabolite Accession: GCST90199964
Name: etiocholanolone glucuronide
Hmdb Id: HMDB0004484
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Denominator Metabolite

Structure of dehydroepiandrosterone sulfate (dhea-s)
Metabolite Accession: GCST90199673
Name: dehydroepiandrosterone sulfate (dhea-s)
Hmdb Id: HMDB0001032
Super Pathway: NA
Sub Pathway: NA
Inchikey: CZWCKYRVOZZJNM

Associated Genomic Regions

Region: rs141232858

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.806
Position:
62874534
SE (Ratio):
0.029
Effect Allele:
C
Z-score (Ratio):
28.104
Reference Allele:
A
-log10(P):
-398.486
MAF:
0.060
Beta (Num):
0.846
Novel Locus:
No
SE (Num):
0.031
Beta (Den):
0.041
SE (Den):
0.028
No CNV overlap
rQTL cluster:
61
Reaction Distance:
NA
Closest Genes:
SLC22A24 SLC22A10 SLC22A25 SLC22A8 SLC22A6

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
19
Beta (Ratio):
0.151
Position:
48374950
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
7.916
Reference Allele:
C
-log10(P):
-33.641
MAF:
0.162
Beta (Num):
0.066
Novel Locus:
Yes ✔️
SE (Num):
0.021
Beta (Den):
-0.085
SE (Den):
0.018
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Androgen Metabolism, Steroidogenesis4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Steroidogenesis, Androgen and Estrogen Metabolism7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects the activity of SULT2A1, which sulfonates DHEA to DHEAS. A lower ratio may indicate reduced SULT2A1 activity.10[1], 11[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

SULT2A1 gene variants are associated with altered DHEAS levels and an increased risk of cholelithiasis.12[1], 13[2] Dysregulation of SULT2A1 may impact bile acid metabolism, a key factor in gallstone formation, linking the genetic factor to the phenotype.12[3], 14[4], 15[5]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data