pregnanediol-3-glucuronide to androstenediol (3beta,17beta) disulfate (2)

Numerator Metabolite

Structure of pregnanediol-3-glucuronide
Metabolite Accession: GCST90199917
Name: pregnanediol-3-glucuronide
Hmdb Id: HMDB0010318
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZFFFJLDTCLJDHL

Denominator Metabolite

Structure of androstenediol (3beta,17beta) disulfate (2)
Metabolite Accession: GCST90199851
Name: androstenediol (3beta,17beta) disulfate (2)
Hmdb Id: HMDB0240313
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWPTUYJASNIIJM

Associated Genomic Regions

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
19
Beta (Ratio):
0.167
Position:
48374950
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
7.627
Reference Allele:
C
-log10(P):
-31.357
MAF:
0.162
Beta (Num):
0.112
Novel Locus:
Yes ✔️
SE (Num):
0.021
Beta (Den):
-0.056
SE (Den):
0.019
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis, Progesterone Metabolism4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Androgen and Estrogen Metabolism7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects SULT2A1 activity, where higher values suggest lower sulfation of androstenediol relative to the glucuronidation of pregnanediol.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in SULT2A1 are associated with altered bile acid and steroid metabolism, which is linked to an increased risk of cholelithiasis.10[1], 11[2], 12[3] SULT2A1 is involved in the sulfation of both androstenediol and bile acids.1[4], 7[5]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data