deoxycholic acid 12-sulfate* to androsterone glucuronide

Numerator Metabolite

Metabolite Accession: GCST90200250
Name: deoxycholic acid 12-sulfate*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.379
Position:
48374950
SE (Ratio):
0.028
Effect Allele:
A
Z-score (Ratio):
-13.369
Reference Allele:
C
-log10(P):
-92.184
MAF:
0.156
Beta (Num):
-0.209
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
0.170
SE (Den):
0.018
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Bile acid biosynthesis

Denominator Metabolite Explanation:

Androgen metabolism

Ratio Explanation:

The ratio reflects the relative activity of SULT2A1-mediated sulfation of deoxycholic acid versus the glucuronidation of androsterone, two separate conjugation pathways.1[1], 4[2], 5[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced SULT2A1 activity is associated with an increased risk of cholelithiasis.6[1], 7[2], 8[3] Decreased sulfation of bile acids, like deoxycholic acid, can contribute to the formation of gallstones.6[4], 9[5], 10[6]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data