taurochenodeoxycholic acid 3-sulfate to androsterone glucuronide

Numerator Metabolite

Structure of taurochenodeoxycholic acid 3-sulfate
Metabolite Accession: GCST90200242
Name: taurochenodeoxycholic acid 3-sulfate
Hmdb Id: HMDB0002486
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJHJZQKOSUFQCX

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs62129966

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.358
Position:
48374950
SE (Ratio):
0.030
Effect Allele:
A
Z-score (Ratio):
-11.777
Reference Allele:
C
-log10(P):
-72.051
MAF:
0.155
Beta (Num):
-0.188
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
0.170
SE (Den):
0.018
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Bile acid metabolism; Sulfation.3[1], 4[2]

Denominator Metabolite Explanation:

Androgen metabolism; Glucuronidation.5[1], 6[2], 7[3]

Ratio Explanation:

This ratio reflects SULT2A1 activity, contrasting bile acid sulfation (numerator) with androgen glucuronidation (denominator), two major hepatic detoxification pathways.8[1], 1[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in SULT2A1 alters bile acid sulfation, impacting bile composition and solubility.9[1], 10[2] This change, reflected in the ratio, increases the risk of cholelithiasis (gallstones), cholecystitis, and associated elevated alkaline phosphatase levels, as confirmed by GWAS studies.11[3], 12[4], 13[5]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data