glycochenodeoxycholate 3-sulfate to 5alpha-androstan-3alpha,17beta-diol monosulfate (2)

Numerator Metabolite

Structure of glycochenodeoxycholate 3-sulfate
Metabolite Accession: GCST90200022
Name: glycochenodeoxycholate 3-sulfate
Hmdb Id: HMDB0002409,HMDB0002497
Super Pathway: NA
Sub Pathway: NA
Inchikey: DKXXSIJHWWVNMO

Denominator Metabolite

Metabolite Accession: GCST90199983
Name: 5alpha-androstan-3alpha,17beta-diol monosulfate (2)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs62129966

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.552
Position:
48374950
SE (Ratio):
0.027
Effect Allele:
A
Z-score (Ratio):
-20.463
Reference Allele:
C
-log10(P):
-212.609
MAF:
0.160
Beta (Num):
-0.303
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.248
SE (Den):
0.017
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Bile acid metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Androgen and steroid metabolism.5[1], 6[2]

Ratio Explanation:

The ratio reflects the relative sulfation activity of the SULT2A1 enzyme on its bile acid and androgen steroid substrates.7[1], 2[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in SULT2A1 can alter the sulfation of bile acids, a process reflected by the metabolite ratio.8[1], 9[2] This dysregulation of bile acid metabolism is a known mechanism in the development of cholelithiasis (gallstones) and associated inflammation like cholecystitis.8[3], 10[4], 11[5]

Phenotype Driver:

Gene-centric:[SULT2A1]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data