pregnenetriol sulfate* to pregnanediol-3-glucuronide

Numerator Metabolite

Structure of pregnenetriol sulfate*
Metabolite Accession: GCST90200241
Name: pregnenetriol sulfate*
Hmdb Id: HMDB0241920
Super Pathway: NA
Sub Pathway: NA
Inchikey: DENIQPHQUIGDJZ

Denominator Metabolite

Structure of pregnanediol-3-glucuronide
Metabolite Accession: GCST90199917
Name: pregnanediol-3-glucuronide
Hmdb Id: HMDB0010318
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZFFFJLDTCLJDHL

Associated Genomic Regions

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.369
Position:
48374950
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
-16.504
Reference Allele:
C
-log10(P):
-139.224
MAF:
0.161
Beta (Num):
-0.257
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.112
SE (Den):
0.021
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Steroid sulfation

Denominator Metabolite Explanation:

Steroid glucuronidation

Ratio Explanation:

The ratio reflects the balance between steroid sulfation, mediated by SULT2A1, and glucuronidation, an alternative pathway for steroid elimination.1[1], 3[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants altering SULT2A1 function impact steroid and bile acid metabolism.1[1], 4[2] This dysregulation can change bile composition, increasing the risk of cholesterol gallstones (cholelithiasis), subsequent gallbladder inflammation (cholecystitis), and related elevations in alkaline phosphatase.4[3], 5[4], 6[5], 7[6]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data