pregnanediol-3-glucuronide to androsterone sulfate

Numerator Metabolite

Structure of pregnanediol-3-glucuronide
Metabolite Accession: GCST90199917
Name: pregnanediol-3-glucuronide
Hmdb Id: HMDB0010318
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZFFFJLDTCLJDHL

Denominator Metabolite

Structure of androsterone sulfate
Metabolite Accession: GCST90200674
Name: androsterone sulfate
Hmdb Id: HMDB0002759
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Associated Genomic Regions

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.242
Position:
48374950
SE (Ratio):
0.026
Effect Allele:
A
Z-score (Ratio):
9.301
Reference Allele:
C
-log10(P):
-45.720
MAF:
0.162
Beta (Num):
0.112
Novel Locus:
Yes ✔️
SE (Num):
0.021
Beta (Den):
-0.130
SE (Den):
0.020
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Progesterone metabolism3[1], 4[2]

Denominator Metabolite Explanation:

Androgen metabolism5[1], 6[2], 7[3]

Ratio Explanation:

The ratio reflects the balance between progesterone and androgen metabolic pathways, where SULT2A1-mediated sulfation influences the clearance of androsterone.1[1], 5[2], 3[3], 6[4], 7[5]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in SULT2A1 are associated with cholelithiasis.8[1], 9[2] SULT2A1's role in steroid and bile acid sulfation is a plausible mechanism; altered sulfation could disrupt bile composition, leading to gallstone formation.1[3], 8[4], 9[5]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data