glycodeoxycholate 3-sulfate to glyco-beta-muricholate**

Numerator Metabolite

Metabolite Accession: GCST90200026
Name: glycodeoxycholate 3-sulfate
Hmdb Id: HMDB0341325
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200179
Name: glyco-beta-muricholate**
Hmdb Id: HMDB0341323
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs296382

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.339
Position:
48370918
SE (Ratio):
0.025
Effect Allele:
C
Z-score (Ratio):
-13.624
Reference Allele:
A
-log10(P):
-95.643
MAF:
0.160
Beta (Num):
-0.247
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.092
SE (Den):
0.023
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Bile acid sulfation

Denominator Metabolite Explanation:

Bile acid metabolism

Ratio Explanation:

The ratio reflects SULT2A1 enzymatic activity, where an increase indicates higher sulfation of glycodeoxycholate relative to the pool of other bile acids.1[1], 2[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in SULT2A1 are associated with cholelithiasis.4[1], 5[2], 6[3] Altered SULT2A1 activity likely changes bile acid composition and solubility, increasing the risk of gallstone formation (cholelithiasis), gallbladder inflammation (cholecystitis), and related liver function abnormalities (elevated ALP).7[4], 8[5], 9[6]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data