pregnenetriol sulfate* to androsterone glucuronide

Numerator Metabolite

Structure of pregnenetriol sulfate*
Metabolite Accession: GCST90200241
Name: pregnenetriol sulfate*
Hmdb Id: HMDB0241920
Super Pathway: NA
Sub Pathway: NA
Inchikey: DENIQPHQUIGDJZ

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs62129966

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.428
Position:
48374950
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
-21.438
Reference Allele:
C
-log10(P):
-233.077
MAF:
0.161
Beta (Num):
-0.257
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.170
SE (Den):
0.018
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Steroid biosynthesis3[1]

Denominator Metabolite Explanation:

Androgen and estrogen metabolism4[1], 5[2]

Ratio Explanation:

The ratio of pregnenetriol sulfate to androsterone glucuronide reflects the balance between steroid hormone synthesis and androgen catabolism, influenced by SULT2A1 activity.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variations in SULT2A1, which sulfates hydroxysteroids, are associated with an increased risk of cholelithiasis.6[1], 7[2] This suggests that altered steroid metabolism, reflected by the pregnenetriol sulfate* to androsterone glucuronide ratio, may contribute to the development of gallstone disease.

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data