pregnenolone sulfate to androsterone glucuronide

Numerator Metabolite

Structure of pregnenolone sulfate
Metabolite Accession: GCST90199873
Name: pregnenolone sulfate
Hmdb Id: HMDB0000774
Super Pathway: NA
Sub Pathway: NA
Inchikey: DIJBBUIOWGGQOP

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.272
Position:
48374950
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
-12.235
Reference Allele:
C
-log10(P):
-77.580
MAF:
0.159
Beta (Num):
-0.102
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.170
SE (Den):
0.018
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Steroid sulfation.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Androgen catabolism, glucuronidation.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects SULT2A1-mediated sulfation of pregnenolone relative to downstream androgen catabolism and clearance, indicating a potential shift in steroid hormone processing.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced SULT2A1 activity, indicated by the ratio, can alter both steroid hormone balance and bile acid sulfation.3[1], 10[2] This dysregulation is a known risk factor for cholelithiasis (gallstones) and subsequent gallbladder inflammation (cholecystitis).11[3], 12[4]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data