androstenediol (3beta,17beta) monosulfate (1) to 5alpha-pregnan-3beta,20alpha-diol monosulfate (2)

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (1)
Metabolite Accession: GCST90199872
Name: androstenediol (3beta,17beta) monosulfate (1)
Hmdb Id: HMDB0240429
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Metabolite Accession: GCST90199854
Name: 5alpha-pregnan-3beta,20alpha-diol monosulfate (2)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
19
Beta (Ratio):
-0.244
Position:
48374950
SE (Ratio):
0.023
Effect Allele:
A
Z-score (Ratio):
-10.508
Reference Allele:
C
-log10(P):
-57.791
MAF:
0.161
Beta (Num):
-0.081
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
0.163
SE (Den):
0.021
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen metabolism.5[1]

Denominator Metabolite Explanation:

Steroid metabolism.6[1], 7[2]

Ratio Explanation:

This ratio reflects the relative activity of SULT2A1 in sulfating androstenediol and pregnanediol, steroids involved in androgen/estrogen and progesterone metabolism respectively.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in SULT2A1, an enzyme that sulfates steroids and bile acids, may alter its activity.1[1], 8[2], 9[3] This could impact the balance of sulfated steroids like androstenediol and pregnanediol, potentially influencing bile composition and contributing to the risk of cholelithiasis.3[4], 4[5], 10[6]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data