androsterone glucuronide to DHEAS

Numerator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Denominator Metabolite

Structure of dehydroepiandrosterone sulfate (dhea-s)
Metabolite Accession: GCST90199673
Name: dehydroepiandrosterone sulfate (dhea-s)
Hmdb Id: HMDB0001032
Super Pathway: NA
Sub Pathway: NA
Inchikey: CZWCKYRVOZZJNM

Associated Genomic Regions

Region: rs62129966

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.255
Position:
48374950
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
13.857
Reference Allele:
C
-log10(P):
-98.869
MAF:
0.162
Beta (Num):
0.170
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.085
SE (Den):
0.018
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Androgen metabolism, Glucuronidation5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Steroid biosynthesis, Sulfation8[1], 9[2], 1[3], 10[4], 11[5], 4[6]

Ratio Explanation:

The ratio reflects the balance between androgen metabolism via glucuronidation (numerator) and DHEA sulfation (denominator), indicating SULT2A1 activity.1[1], 5[2], 6[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced SULT2A1 activity decreases DHEAS, altering the ratio. SULT2A1 is genetically associated with cholelithiasis, potentially through its role in bile acid and steroid metabolism.12[1], 13[2], 14[3]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data