5alpha-androstan-3alpha,17beta-diol monosulfate (1) to androsterone glucuronide

Numerator Metabolite

Metabolite Accession: GCST90199858
Name: 5alpha-androstan-3alpha,17beta-diol monosulfate (1)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs62129966

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.347
Position:
48374950
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
-15.514
Reference Allele:
C
-log10(P):
-123.318
MAF:
0.162
Beta (Num):
-0.177
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.170
SE (Den):
0.018
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

Region: rs976058

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Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
0.222
Position:
69341487
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
13.077
Reference Allele:
T
-log10(P):
-88.304
MAF:
0.400
Beta (Num):
0.170
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.053
SE (Den):
0.014
No CNV overlap
rQTL cluster:
124
Reaction Distance:
NA
Closest Genes:
TMPRSS11E UGT2B17 YTHDC1 UGT2B15 TMPRSS11B

LLM Analysis

Numerator Metabolite Explanation:

steroid sulfation

Denominator Metabolite Explanation:

Androgen metabolism, glucuronidation14[1], 15[2], 16[3], 17[4]

Ratio Explanation:

The ratio reflects the balance between sulfation and glucuronidation of androgens, with a higher ratio indicating increased SULT2A1 activity relative to UGT2B15/UGT2B17.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

SULT2A1 genetic variants influence its enzymatic activity, altering the ratio of sulfated to glucuronidated androgens.18[1] This alteration in steroid metabolism, particularly bile acid sulfation by SULT2A119[2], 20[3], 21[4], 22[5], 23[6], is associated with cholelithiasis risk.5[7], 24[8], 6[9], 7[10], 8[11], 9[12], 10[13], 11[14], 12[15]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data