glycodeoxycholate 3-sulfate to androsterone glucuronide

Numerator Metabolite

Metabolite Accession: GCST90200026
Name: glycodeoxycholate 3-sulfate
Hmdb Id: HMDB0341325
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs62129966

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.420
Position:
48374950
SE (Ratio):
0.028
Effect Allele:
A
Z-score (Ratio):
-15.041
Reference Allele:
C
-log10(P):
-116.062
MAF:
0.160
Beta (Num):
-0.250
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.170
SE (Den):
0.018
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Bile acid metabolism

Denominator Metabolite Explanation:

Steroid hormone biosynthesis

Ratio Explanation:

This ratio reflects the activity of SULT2A1, which sulfates both bile acids like glycodeoxycholate and steroids like androsterone, preparing them for elimination.1[1], 2[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced SULT2A1 activity can impair bile acid sulfation, leading to an accumulation of non-sulfated bile acids, which is a risk factor for cholelithiasis (gallstones).3[1], 4[2], 5[3]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data