deoxycholic acid 12-sulfate* to 5alpha-androstan-3alpha,17beta-diol monosulfate (2)

Numerator Metabolite

Metabolite Accession: GCST90200250
Name: deoxycholic acid 12-sulfate*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90199983
Name: 5alpha-androstan-3alpha,17beta-diol monosulfate (2)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs296381

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.461
Position:
48371102
SE (Ratio):
0.028
Effect Allele:
C
Z-score (Ratio):
-16.279
Reference Allele:
T
-log10(P):
-135.524
MAF:
0.157
Beta (Num):
-0.214
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
0.247
SE (Den):
0.017
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Bile acid metabolism.5[1]

Denominator Metabolite Explanation:

Androgen and steroid metabolism.

Ratio Explanation:

The ratio reflects the relative activity of SULT2A1 on bile acids versus androgens, where higher values suggest a preference for sulfating deoxycholic acid over 5alpha-androstan-3alpha,17beta-diol.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in SULT2A1 are associated with altered bile acid sulfation.6[1] Dysregulation of bile acid homeostasis is a known mechanism in cholelithiasis development, and lower SULT2A1 expression, potentially influenced by genetic factors, is linked to an increased risk of gallstones.7[2], 8[3]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data