pregnanediol-3-glucuronide to pregnenediol sulfate (c21h34o5s)*

Numerator Metabolite

Structure of pregnanediol-3-glucuronide
Metabolite Accession: GCST90199917
Name: pregnanediol-3-glucuronide
Hmdb Id: HMDB0010318
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZFFFJLDTCLJDHL

Denominator Metabolite

Structure of pregnenediol sulfate (c21h34o5s)*
Metabolite Accession: GCST90199861
Name: pregnenediol sulfate (c21h34o5s)*
Hmdb Id: HMDB0000774
Super Pathway: NA
Sub Pathway: NA
Inchikey: DIJBBUIOWGGQOP

Associated Genomic Regions

Region: rs4148415

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Clumped rQTL variant

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SNP Summary

Chr:
17
Beta (Ratio):
-0.123
Position:
48752600
SE (Ratio):
0.015
Effect Allele:
T
Z-score (Ratio):
-8.357
Reference Allele:
C
-log10(P):
-37.285
MAF:
0.355
Beta (Num):
-0.102
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.021
SE (Den):
0.014
No CNV overlap
rQTL cluster:
19
Reaction Distance:
NA
Closest Genes:
ABCC3 ANKRD40 LUC7L3 CACNA1G SPATA20

Region: rs62129966

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.244
Position:
48374950
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
12.716
Reference Allele:
C
-log10(P):
-83.627
MAF:
0.162
Beta (Num):
0.112
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
-0.133
SE (Den):
0.018
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Steroid hormone biosynthesis6[1]

Denominator Metabolite Explanation:

Steroid metabolism, sulfation7[1]

Ratio Explanation:

This ratio reflects the balance between glucuronidation and sulfation of pregnanediol. A higher ratio suggests a shift towards glucuronidation, potentially influenced by SULT2A1 activity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SULT2A1 function likely affects bile acid and steroid metabolism.1[1], 2[2], 3[3], 4[4] This dysregulation can contribute to the formation of gallstones (cholelithiasis)8[5], 9[6], 10[7], 11[8], a condition associated with changes in bile composition and gallbladder function.12[9], 13[10], 11[11]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data