5alpha-pregnan-3beta,20alpha-diol monosulfate (2) to 5alpha-androstan-3beta,17beta-diol monosulfate (2)

Numerator Metabolite

Metabolite Accession: GCST90199854
Name: 5alpha-pregnan-3beta,20alpha-diol monosulfate (2)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90199855
Name: 5alpha-androstan-3beta,17beta-diol monosulfate (2)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs10426201

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.244
Position:
48384749
SE (Ratio):
0.025
Effect Allele:
G
Z-score (Ratio):
9.641
Reference Allele:
A
-log10(P):
-48.974
MAF:
0.166
Beta (Num):
0.159
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
-0.085
SE (Den):
0.021
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 BSPH1

LLM Analysis

Numerator Metabolite Explanation:

Steroid sulfation4[1], 5[2]

Denominator Metabolite Explanation:

Steroid sulfation6[1], 7[2]

Ratio Explanation:

The ratio reflects the relative activity of SULT2A1 on pregnane and androstane steroid precursors, indicating a preference or efficiency of sulfation between these two steroid classes.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in SULT2A1 alter its enzymatic activity, affecting the balance of sulfated steroids and bile acids, which is a known risk factor for cholelithiasis (gallstone disease).8[1], 9[2], 10[3]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data