androstenediol (3beta,17beta) monosulfate (1) to pregnanediol-3-glucuronide

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (1)
Metabolite Accession: GCST90199872
Name: androstenediol (3beta,17beta) monosulfate (1)
Hmdb Id: HMDB0240429
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Structure of pregnanediol-3-glucuronide
Metabolite Accession: GCST90199917
Name: pregnanediol-3-glucuronide
Hmdb Id: HMDB0010318
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZFFFJLDTCLJDHL

Associated Genomic Regions

Region: rs62129966

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.193
Position:
48374950
SE (Ratio):
0.023
Effect Allele:
A
Z-score (Ratio):
-8.325
Reference Allele:
C
-log10(P):
-37.016
MAF:
0.161
Beta (Num):
-0.081
Novel Locus:
Yes ✔️
SE (Num):
0.018
Beta (Den):
0.112
SE (Den):
0.021
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Progesterone metabolism.6[1], 7[2]

Ratio Explanation:

This ratio reflects the balance between sulfated androgen excretion (numerator) and glucuronidated progesterone excretion (denominator), potentially modulated by SULT2A1 activity on steroid metabolism.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in SULT2A1 are associated with cholelithiasis risk.8[1], 9[2] SULT2A1 catalyzes the sulfation of androgens and bile acids, and altered function can lead to bile acid accumulation and cholesterol gallstone formation.1[3], 3[4], 10[5], 8[6] The ratio may reflect this altered steroid/bile acid metabolism.

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data