5alpha-androstan-3beta,17beta-diol monosulfate (2) to androsterone glucuronide

Numerator Metabolite

Metabolite Accession: GCST90199855
Name: 5alpha-androstan-3beta,17beta-diol monosulfate (2)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs62129966

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.253
Position:
48374950
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
-11.377
Reference Allele:
C
-log10(P):
-67.382
MAF:
0.162
Beta (Num):
-0.083
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.170
SE (Den):
0.018
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

Region: rs2123886

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Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
-0.160
Position:
69328887
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
-8.616
Reference Allele:
A
-log10(P):
-39.506
MAF:
0.292
Beta (Num):
-0.107
Novel Locus:
Yes ✔️
SE (Num):
0.018
Beta (Den):
0.053
SE (Den):
0.015
No CNV overlap
rQTL cluster:
124
Reaction Distance:
NA
Closest Genes:
TMPRSS11E UGT2B17 YTHDC1 UGT2B15 TMPRSS11B

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen metabolism

Denominator Metabolite Explanation:

Androgen and estrogen metabolism

Ratio Explanation:

The ratio reflects the balance between sulfation and glucuronidation of androgen metabolites, influenced by SULT2A1 activity on the numerator's precursors.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in SULT2A1, a gene involved in steroid and bile acid metabolism, may alter its activity.1[1], 2[2], 3[3] This could influence the balance of sex hormone metabolites and bile acid profiles, potentially contributing to the development of cholelithiasis and hypercholesterolemia.4[4], 5[5], 6[6]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data