pregnenediol disulfate (c21h34o8s2)* to androsterone glucuronide

Numerator Metabolite

Metabolite Accession: GCST90199840
Name: pregnenediol disulfate (c21h34o8s2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs62129966

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.680
Position:
48374950
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
-30.526
Reference Allele:
C
-log10(P):
-469.573
MAF:
0.160
Beta (Num):
-0.509
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
0.170
SE (Den):
0.018
No CNV overlap
rQTL cluster:
7
Reaction Distance:
NA
Closest Genes:
SULT2A1 TPRX2P CRX TPRX1 SEPW1

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis, steroid sulfation.3[1]

Denominator Metabolite Explanation:

Androgen metabolism, steroid glucuronidation.4[1], 5[2]

Ratio Explanation:

This ratio reflects the balance between steroid sulfation (pregnenediol disulfate) and glucuronidation (androsterone glucuronide), influenced by SULT2A1 activity on steroid precursors.6[1], 7[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in SULT2A1, which sulfates bile acids and steroids, is linked to cholelithiasis.8[1] Altered SULT2A1 activity can disrupt cholesterol and bile acid metabolism, increasing the risk of gallstones, with the steroid ratio serving as a biomarker of this activity.9[2], 10[3]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data